The gut-mood axis: a novel role of the gut hormone peptide YY on emotional-affective behaviour in mice
نویسندگان
چکیده
Background Peptide YY (PYY) and neuropeptide Y (NPY) are members of the PP-fold peptide family. PYY is expressed by endocrine cells of the gut, whereas NPY occurs in enteric, sensory, cerebral and autonomic neurons. While PYY is involved in the regulation of gut function and satiety, NPY is known to contribute to the regulation of emotionalaffective behaviour, cognition, seizure activity, pain and satiety. Since we have previously found that the NPY system plays a role in the gut-brain axis, we explored in which way knockout of PYY and PYY plus NPY alters the emotional-affective behaviour in mice and how this phenotype is altered by experimental colitis.
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